![]() Provision of early gastrointestinal decontamination with activated charcoal and whole-bowel irrigation might mitigate this. Peak toxicity can be delayed by several hours. Additionally, CCBs, such as verapamil and diltiazem, are commonly ingested in sustained-release formulations. ![]() ![]() CCBs can also produce vasodilatory shock. Significant myocardial depression, bradycardia and hypotension result in both cases. Management of cardiovascular instability resulting from calcium channel antagonist (CCB) or beta-adrenergic receptor antagonist (BB) poisoning follows similar principles.
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